Salmonella Typhi Bactericidal Antibodies Reduce Disease Severity but Do Not Protect against Typhoid Fever in a Controlled Human Infection Model

Salmonella Typhi Bactericidal Antibodies Reduce Disease Severity but Do Not Protect against Typhoid Fever in a Controlled Human Infection Model

Effective vaccines against Salmonella Typhi, a major cause of febrile illness in tropical regions, can have a significant effect as a disease control measure. Earlier work has shown that immunization with either of two Salmonella Typhi vaccines, licensed Ty21a or candidate M01ZH09, did not provide f...

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Bibliographic Details
Main Authors: Helene B. Juel, Helena B. Thomaides-Brears, Thomas C. Darton, Claire Jones, Elizabeth Jones, Sonu Shrestha, Rebecca Sie, Andrew Eustace, Ushma Galal, Prathiba Kurupati, Tan T. Van, Nga T. V. Thieu, Stephen Baker, Christoph J. Blohmke, Andrew J. Pollard
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
typhoid infection
bactericidal activity
human challenge model
Salmonella enterica Typhi
immune responses
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01916/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01916/full

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