DNA double strand breaks as predictor of efficacy of the alpha-particle emitter Ac-225 and the electron emitter Lu-177 for somatostatin receptor targeted radiotherapy.

DNA double strand breaks as predictor of efficacy of the alpha-particle emitter Ac-225 and the electron emitter Lu-177 for somatostatin receptor targeted radiotherapy.

RATIONALE: Key biologic effects of the alpha-particle emitter Actinium-225 in comparison to the beta-particle emitter Lutetium-177 labeled somatostatin-analogue DOTATOC in vitro and in vivo were studied to evaluate the significance of γH2AX-foci formation. METHODS: To determine the relative biologic...

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Bibliographic Details
Main Authors: Franziska Graf, Jörg Fahrer, Stephan Maus, Alfred Morgenstern, Frank Bruchertseifer, Senthil Venkatachalam, Christian Fottner, Matthias M Weber, Johannes Huelsenbeck, Mathias Schreckenberger, Bernd Kaina, Matthias Miederer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3917860?pdf=render

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http://europepmc.org/articles/PMC3917860?pdf=render

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