Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression

Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression

<p>Abstract</p> <p>Background</p> <p>Endophenotypes are heritable markers, which are more prevalent in patients and their healthy relatives than in the general population. Recent studies point at disturbed regulation of the hypothalamic-pituitary-adrenocortical axis as...

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Bibliographic Details
Main Authors: Paulson Olaf, Haastrup Eva, Gade Anders, Hilsted Linda, Feldt-Rasmussen Ulla, Klose Marianne, Vinberg Maj, Knorr Ulla, Wetterslev Jørn, Gluud Christian, Gether Ulrik, Kessing Lars
Format: Article
Language:English
Published: BMC 2009-08-01
Series:Trials
Online Access:http://www.trialsjournal.com/content/10/1/66

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http://www.trialsjournal.com/content/10/1/66

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