Low VDAC1 Expression Is Associated with an Aggressive Phenotype and Reduced Overall Patient Survival in Cholangiocellular Carcinoma

Low VDAC1 Expression Is Associated with an Aggressive Phenotype and Reduced Overall Patient Survival in Cholangiocellular Carcinoma

Cancer cells frequently exhibit dysfunctional oxidative phosphorylation (OXPHOS) and a concomitant increase in glycolytic flux. We investigated the expression of OXPHOS complex subunits and mitochondrial mass in 34 human cholangiocellular carcinomas (CCCs) and adjacent normal tissue by using tissue...

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Bibliographic Details
Main Authors: René Günther Feichtinger, Daniel Neureiter, Ralf Kemmerling, Johannes Adalbert Mayr, Tobias Kiesslich, Barbara Kofler
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
cholangiocellular carcinoma
mitochondria
energy metabolism
oxidative phosphorylation
Online Access:https://www.mdpi.com/2073-4409/8/6/539

Internet

https://www.mdpi.com/2073-4409/8/6/539

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