Comparative study of anti-inflammatory, ulcerogenic and cytotoxic activities of racemate and S-ibuprofen

Comparative study of anti-inflammatory, ulcerogenic and cytotoxic activities of racemate and S-ibuprofen

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Ibuprofen is widely commercialized in racemic form. Although metabolic chiral inversion occurs through the conversion of R(-)-ibuprofen to S(+)-ibuprofen and the latter enantiomer is considered the active form, clinical trials involving the administration of a racemate to S-enantiomer dosage ratio o...

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Bibliographic Details
Main Authors: Flavio Henrique Nuevo Benez, Caroline Candida de Oliveira, Simone Coghetto Acedo, Erica Martins Ferreira Gotardo, Lara Ester Câmara, Silvana Calafatti, Patricia Oliveira Carvalho, Alessandra Gambero
Format: Article
Language:English
Published: São Paulo State University (UNESP) 2013-07-01
Series:Revista de Ciências Farmacêuticas Básica e Aplicada
Subjects:
ibuprofen. enantiomers. air pouch model. pge 2. gastric ulcers.
Online Access:http://rcfba.fcfar.unesp.br/index.php/ojs/article/view/192

Internet

http://rcfba.fcfar.unesp.br/index.php/ojs/article/view/192

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