Role of Mitochondrial Complex IV in Age-Dependent Obesity

Role of Mitochondrial Complex IV in Age-Dependent Obesity

Aging is associated with progressive white adipose tissue (WAT) enlargement initiated early in life, but the molecular mechanisms involved remain unknown. Here we show that mitochondrial complex IV (CIV) activity and assembly are already repressed in white adipocytes of middle-aged mice and involve...

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Bibliographic Details
Main Authors: Ines Soro-Arnaiz, Qilong Oscar Yang Li, Mar Torres-Capelli, Florinda Meléndez-Rodríguez, Sónia Veiga, Koen Veys, David Sebastian, Ainara Elorza, Daniel Tello, Pablo Hernansanz-Agustín, Sara Cogliati, Jose Maria Moreno-Navarrete, Eduardo Balsa, Esther Fuertes, Eduardo Romanos, Antonio Martínez-Ruiz, Jose Antonio Enriquez, Jose Manuel Fernandez-Real, Antonio Zorzano, Katrien De Bock, Julián Aragonés
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
mitochondrial complex IV
mitochondrial dysfunction
COX5B
aging
white adipocytes
obesity
HIF-1
human adipose tissue
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716311056

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http://www.sciencedirect.com/science/article/pii/S2211124716311056

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