Establishment of self-renewable GM-CSF-dependent immature macrophages in vitro from murine bone marrow.

Macrophages play a key role in the innate immune system. Macrophages are thought to originate from hematopoietic precursors or the yolk sac. Here, we describe the in vitro establishment of self-renewable GM-CSF-dependent immature macrophages (GM-IMs) from murine bone marrow (BM). GM-IMs grow continu...

Full description

Bibliographic Details
Main Authors: Sachiko Ito, Yuriko Tanaka, Naomi Nishio, Suganya Thanasegaran, Ken-Ichi Isobe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3790761?pdf=render