Lack of WWC2 Protein Leads to Aberrant Angiogenesis in Postnatal Mice

Lack of WWC2 Protein Leads to Aberrant Angiogenesis in Postnatal Mice

The WWC protein family is an upstream regulator of the Hippo signalling pathway that is involved in many cellular processes. We examined the effect of an endothelium-specific WWC1 and/or WWC2 knock-out on ocular angiogenesis. Knock-outs were induced in C57BL/6 mice at the age of one day (P1) and eva...

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Bibliographic Details
Main Authors: Viktoria Constanze Brücher, Charlotte Egbring, Tanja Plagemann, Pavel I. Nedvetsky, Verena Höffken, Hermann Pavenstädt, Nicole Eter, Joachim Kremerskothen, Peter Heiduschka
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
WWC protein
angiogenesis
Hippo signalling pathway
hypersprouting
endothelial cell specific knock-out
Online Access:https://www.mdpi.com/1422-0067/22/10/5321

Internet

https://www.mdpi.com/1422-0067/22/10/5321

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