Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity

During cocaine-induced hepatotoxicity, lipid accumulation occurs prior to necrotic cell death in the liver. However, the exact influences of cocaine on the homeostasis of lipid metabolism remain largely unknown. In this study, the progression of subacute hepatotoxicity, including centrilobular necro...

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Bibliographic Details
Main Authors: Xiaolei Shi, Dan Yao, Blake A. Gosnell, Chi Chen
Format: Article
Language:English
Published: Elsevier 2012-11-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520412490