Pharmacological Inhibition and Genetic Knockdown of BCL9 Modulate the Cellular Landscape of Cancer-Associated Fibroblasts in the Tumor-Immune Microenvironment of Colorectal Cancer

Pharmacological Inhibition and Genetic Knockdown of BCL9 Modulate the Cellular Landscape of Cancer-Associated Fibroblasts in the Tumor-Immune Microenvironment of Colorectal Cancer

Cancer-associated fibroblasts (CAFs) exert a key role in cancer progression and liver metastasis. They are activated in the tumor microenvironment (TME), but their prometastatic mechanisms are not defined. CAFs are abundant in colorectal cancer (CRC). However, it is not clear whether they are raised...

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Bibliographic Details
Main Authors: Mengxuan Yang, Zhuang Wei, Mei Feng, Yuanyuan Zhu, Yong Chen, Di Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
cancer-associated fibroblasts
Wnt signaling
BCL9
tumor immune microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.603556/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.603556/full

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