Dose and timing of injections for effective cyclosporine A pretreatment before renal ischemia reperfusion in mice.

Dose and timing of injections for effective cyclosporine A pretreatment before renal ischemia reperfusion in mice.

There is experimental evidence that lethal ischemia-reperfusion injury (IRI) is largely due to mitochondrial permeability transition pore (mPTP) opening, which can be prevented by cyclosporine A (CsA). The aim of our study is to show that a higher dose of CsA (10 mg/kg) injected just before ischemia...

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Bibliographic Details
Main Authors: Sandrine Lemoine, Bruno Pillot, Lionel Augeul, Maud Rabeyrin, Annie Varennes, Gabrielle Normand, Delphine Baetz, Michel Ovize, Laurent Juillard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5552114?pdf=render

Internet

http://europepmc.org/articles/PMC5552114?pdf=render

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