Vectorized Delivery of Alpha-GalactosylCeramide and Tumor Antigen on Filamentous Bacteriophage fd Induces Protective Immunity by Enhancing Tumor-Specific T Cell Response

Vectorized Delivery of Alpha-GalactosylCeramide and Tumor Antigen on Filamentous Bacteriophage fd Induces Protective Immunity by Enhancing Tumor-Specific T Cell Response

We have exploited the properties of filamentous bacteriophage fd to deliver immunologically active lipids together with antigenic peptides. Filamentous bacteriophages resemble for size, capability to be permeable to blood vessels, and high density antigen expression, a nature-made nanoparticle. In a...

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Bibliographic Details
Main Authors: Rossella Sartorius, Luciana D’Apice, Pasquale Barba, Deborah Cipria, Laura Grauso, Adele Cutignano, Piergiuseppe De Berardinis
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
vectorized alpha-GalactosylCeramide
filamentous bacteriophage
invariant Natural Killer T cells
anti-tumor immunity
CD8+ T Cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01496/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01496/full

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