Identification of gene mutations in patients with primary periodic paralysis using targeted next-generation sequencing

Identification of gene mutations in patients with primary periodic paralysis using targeted next-generation sequencing

Abstract Background Primary periodic paralysis is characterized by recurrent quadriplegia typically associated with abnormal serum potassium levels. The molecular diagnosis of primary PP previously based on Sanger sequencing of hot spots or exon-by-exon screening of the reported genes. Methods We de...

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Bibliographic Details
Main Authors: Sushan Luo, Minjie Xu, Jian Sun, Kai Qiao, Jie Song, Shuang Cai, Wenhua Zhu, Lei Zhou, Jianying Xi, Jiahong Lu, Xiaohua Ni, Tonghai Dou, Chongbo Zhao
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Neurology
Subjects:
Primary periodic paralysis
Targeted next-generation sequencing
Gene panel
Gene mutation distribution
Calcium homeostasis.
Online Access:http://link.springer.com/article/10.1186/s12883-019-1322-6

Internet

http://link.springer.com/article/10.1186/s12883-019-1322-6

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