Neutrophil Extracellular Traps Reprogram IL-4/GM-CSF-Induced Monocyte Differentiation to Anti-inflammatory Macrophages

Neutrophil Extracellular Traps Reprogram IL-4/GM-CSF-Induced Monocyte Differentiation to Anti-inflammatory Macrophages

Monocyte-derived dendritic cells (mo-DCs) are essential for the development of a Th1 protective immune response against Leishmania parasites. It is well known that IL-4 and GM-CSF drive differentiation of human monocytes to dendritic cells (DCs). Here, we investigate if neutrophil extracellular trap...

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Bibliographic Details
Main Authors: Anderson B. Guimarães-Costa, Natalia C. Rochael, Fabiano Oliveira, Juliana Echevarria-Lima, Elvira M. Saraiva
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
neutrophil extracellular traps
monocytes
IL-4 receptor
elastase
dendritic cells
Leishmania
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00523/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00523/full

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