Action Potential Recording and Pro-arrhythmia Risk Analysis in Human Ventricular Trabeculae

Action Potential Recording and Pro-arrhythmia Risk Analysis in Human Ventricular Trabeculae

To assess drug-induced pro-arrhythmic risk, especially Torsades de Pointe (TdP), new models have been proposed, such as in-silico modeling of ventricular action potential (AP) and stem cell-derived cardiomyocytes (SC-CMs). Previously we evaluated the electrophysiological profile of 15 reference drug...

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Bibliographic Details
Main Authors: Yusheng Qu, Guy Page, Najah Abi-Gerges, Paul E. Miller, Andre Ghetti, Hugo M. Vargas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Physiology
Subjects:
action potential
Pro-arrhythmic risk
human ventricular tissue
TdP assessement
In-vitro models
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.01109/full

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