Lean Body Mass Harbors Sensing Mechanisms that Allow Safeguarding of Methionine Homeostasis
Protein-depleted states generate allosteric inhibition of liver cystathionine β-synthase (CBS), which governs the first enzymatic step of the transsulfuration cascade, resulting in upstream accretion of homocysteine (Hcy) in body fluids. A similar Hcy increase may arise from normal hepatocytes under...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/9/9/1035 |