Synthesis and Cytoprotective Characterization of 8-Hydroxyquinoline Betti Products

Synthesis and Cytoprotective Characterization of 8-Hydroxyquinoline Betti Products

The 8-hydroxyquinoline pharmacophore scaffold has been shown to possess a range of activities as metal chelation, enzyme inhibition, cytotoxicity, and cytoprotection. Based on our previous findings we set out to optimize the scaffold for cytoprotective activity for its potential application in centr...

Full description

Bibliographic Details
Main Authors: Iván Kanizsai, Ramóna Madácsi, László Hackler Jr., Márió Gyuris, Gábor J. Szebeni, Orsolya Huzián, László G. Puskás
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
8-hydroxyquinoline
8-HQ
Mannich-reaction
Betti-reaction
multicomponent reaction
cytoprotection
phenotypic screening
neurodegeneration
multitarget directed ligand
mitochondrial membrane potential
HIF1A
Online Access:http://www.mdpi.com/1420-3049/23/8/1934

Internet

http://www.mdpi.com/1420-3049/23/8/1934

Similar Items