Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies1

Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies1

Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid involved in multiple physiological processes. Importantly, dysregulated S1P levels are associated with several pathologies, including cardiovascular and inflammatory diseases and cancer. This report describes the successful production an...

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Bibliographic Details
Main Authors: Nicole O'Brien, S. Tarran Jones, David G. Williams, H. Brad Cunningham, Kelli Moreno, Barbara Visentin, Angela Gentile, John Vekich, William Shestowsky, Masao Hiraiwa, Rosalia Matteo, Amy Cavalli, Douglas Grotjahn, Maria Grant, Geneviève Hansen, Mary-Ann Campbell, Roger Sabbadini
Format: Article
Language:English
Published: Elsevier 2009-11-01
Series:Journal of Lipid Research
Subjects:
sphingosine-1-phosphate
monoclonal antibodies
angiogenesis
cancer
bioactive lipids
humanization
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520306908

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http://www.sciencedirect.com/science/article/pii/S0022227520306908

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