Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice.

Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice.

Cysteine protease cathepsins are important in extracellular matrix protein degradation, cell apoptosis, and angiogenesis. Mice lacking cathepsins are protected from tumor progression in several animal models, suggesting that the regulation of cathepsin activities controls the growth of various malig...

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Bibliographic Details
Main Authors: Weifang Yu, Jian Liu, Michael A Shi, Jianan Wang, Meixiang Xiang, Shiro Kitamoto, Bing Wang, Galina K Sukhova, George F Murphy, Gabriela Orasanu, Anders Grubb, Guo-Ping Shi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2981574?pdf=render

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http://europepmc.org/articles/PMC2981574?pdf=render

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