Genome-wide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages.

Genome-wide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages.

HIV-1 infected macrophages play an important role in rendering resting T cells permissive for infection, in spreading HIV-1 to T cells, and in the pathogenesis of AIDS dementia. During highly active anti-retroviral treatment (HAART), macrophages keep producing virus because tissue penetration of ant...

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Bibliographic Details
Main Authors: Sebastiaan M Bol, Perry D Moerland, Sophie Limou, Yvonne van Remmerden, Cédric Coulonges, Daniëlle van Manen, Joshua T Herbeck, Jacques Fellay, Margit Sieberer, Jantine G Sietzema, Ruben van 't Slot, Jeremy Martinson, Jean-François Zagury, Hanneke Schuitemaker, Angélique B van 't Wout
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3045405?pdf=render

Internet

http://europepmc.org/articles/PMC3045405?pdf=render

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