Accelerated immunodeficiency by anti-CCR5 treatment in HIV infection.

In 50% of progressing HIV-1 patients, CXCR4-tropic (X4) virus emerges late in infection, often overtaking CCR5-tropic (R5) virus as the dominant viral strain. This "phenotypic switch" is strongly associated with rapidly declining CD4(+) T cell counts and AIDS onset, yet its causes remain u...

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Bibliographic Details
Main Authors: Ariel D Weinberger, Alan S Perelson, Ruy M Ribeiro, Leor S Weinberger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2715863?pdf=render