The Human Cytomegalovirus Chemokine vCXCL-1 Modulates Normal Dissemination Kinetics of Murine Cytomegalovirus In Vivo

The Human Cytomegalovirus Chemokine vCXCL-1 Modulates Normal Dissemination Kinetics of Murine Cytomegalovirus In Vivo

An adequate in vivo analysis of HCMV’s viral chemokine vCXCL-1 has been lacking. Here we generate recombinant MCMVs expressing vCXCL-1 to study vCXCL-1 function in vivo using MCMV as a surrogate. We demonstrate that vCXCL-1 increases MCMV dissemination kinetics for both primary and secondary dissemi...

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Bibliographic Details
Main Authors: Joseph W. Jackson, Trevor J. Hancock, Ellen LaPrade, Pranay Dogra, Eric R. Gann, Thomas J. Masi, Ravichandran Panchanathan, William E. Miller, Steven W. Wilhelm, Tim E. Sparer
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mBio
Subjects:
betaherpesvirus
neutrophils
vCXCL-1
viral chemokines
cytomegalovirus
MCMV
Online Access:https://doi.org/10.1128/mBio.01289-19

Internet

https://doi.org/10.1128/mBio.01289-19

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