Detection of haplotype-dependent allele-specific DNA methylation in WGBS data

Allele-specific measurements can reveal differences in DNA methylation between homologous alleles associated with changes in genetic sequence. Here, the authors develop a method for detecting allele specific methylation events within haplotypes of linked SNPs, compare it with existing methods, and s...

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Bibliographic Details
Main Authors: J. Abante, Y. Fang, A. P. Feinberg, J. Goutsias
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19077-1