Association of LRP1B Mutation With Tumor Mutation Burden and Outcomes in Melanoma and Non-small Cell Lung Cancer Patients Treated With Immune Check-Point Blockades

Association of LRP1B Mutation With Tumor Mutation Burden and Outcomes in Melanoma and Non-small Cell Lung Cancer Patients Treated With Immune Check-Point Blockades

Background: Tumor mutation burden (TMB) have been served as the most prevalent biomarkers to predict immunotherapy response. LRP1B (low-density lipoprotein receptor-related protein 1B) is frequently mutated in melanoma, non-small cell lung cancer (NSCLC) and other tumors; however, its association wi...

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Bibliographic Details
Main Authors: Hao Chen, Wei Chong, Qian Wu, Yueliang Yao, Min Mao, Xin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
LRP1B
melanoma
NSCLC
tumor mutation burden
immunotherapy
mutation signatures
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01113/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01113/full

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