Conserved Gene Microsynteny Unveils Functional Interaction Between Protein Disulfide Isomerase and Rho Guanine-Dissociation Inhibitor Families

Conserved Gene Microsynteny Unveils Functional Interaction Between Protein Disulfide Isomerase and Rho Guanine-Dissociation Inhibitor Families

Abstract Protein disulfide isomerases (PDIs) support endoplasmic reticulum redox protein folding and cell-surface thiol-redox control of thrombosis and vascular remodeling. The family prototype PDIA1 regulates NADPH oxidase signaling and cytoskeleton organization, however the related underlying mech...

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Bibliographic Details
Main Authors: Ana I. S. Moretti, Jessyca C. Pavanelli, Patrícia Nolasco, Matthias S. Leisegang, Leonardo Y. Tanaka, Carolina G. Fernandes, João Wosniak, Daniela Kajihara, Matheus H. Dias, Denise C. Fernandes, Hanjoong Jo, Ngoc-Vinh Tran, Ingo Ebersberger, Ralf P. Brandes, Diego Bonatto, Francisco R. M. Laurindo
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-16947-5

Internet

https://doi.org/10.1038/s41598-017-16947-5

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