Effects of the Autophagy-Inhibiting Agent Chloroquine on Acute Myeloid Leukemia Cells; Characterization of Patient Heterogeneity

Effects of the Autophagy-Inhibiting Agent Chloroquine on Acute Myeloid Leukemia Cells; Characterization of Patient Heterogeneity

Autophagy is a highly conserved cellular degradation process that prevents cell damage and promotes cell survival, and clinical efforts have exploited autophagy inhibition as a therapeutic strategy in cancer. Chloroquine is a well-known antimalarial agent that inhibits late-stage autophagy. We evalu...

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Bibliographic Details
Main Authors: Ida Sofie Grønningsæter, Håkon Reikvam, Elise Aasebø, Sushma Bartaula-Brevik, Maria Hernandez-Valladares, Frode Selheim, Frode S. Berven, Tor Henrik Tvedt, Øystein Bruserud, Kimberley Joanne Hatfield
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Journal of Personalized Medicine
Subjects:
acute myeloid leukemia
apoptosis
chemokine
chloroquine
cytokine
proliferation
Online Access:https://www.mdpi.com/2075-4426/11/8/779

Internet

https://www.mdpi.com/2075-4426/11/8/779

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