Perinatal IL-1β-induced inflammation suppresses Tbr2+ intermediate progenitor cell proliferation in the developing hippocampus accompanied by long-term behavioral deficits

Perinatal IL-1β-induced inflammation suppresses Tbr2+ intermediate progenitor cell proliferation in the developing hippocampus accompanied by long-term behavioral deficits

Meta-analyses have revealed associations between the incidence of maternal infections during pregnancy, premature birth, smaller brain volumes, and subsequent cognitive, motor and behavioral deficits as these children mature. Inflammation during pregnancy in rodents produces cognitive and behavioral...

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Bibliographic Details
Main Authors: Stephanie Veerasammy, Juliette Van Steenwinckel, Tifenn Le Charpentier, Joon Ho Seo, Bobbi Fleiss, Pierre Gressens, Steven W. Levison
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Systemic inflammation
Brain development
Anxiety
Memory
Maternal immune activation
Neurogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354620300715

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http://www.sciencedirect.com/science/article/pii/S2666354620300715

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