The Ratio of Regulatory (FOXP3+) to Total (CD3+) T Cells Determined by Epigenetic Cell Counting and Cardiovascular Disease Risk: A Prospective Case-cohort Study in Non-diabetics

The Ratio of Regulatory (FOXP3+) to Total (CD3+) T Cells Determined by Epigenetic Cell Counting and Cardiovascular Disease Risk: A Prospective Case-cohort Study in Non-diabetics

Background: Experimental and clinical evidence indicate that inflammatory processes in atherogenesis and the development of cardiovascular complications are promoted by a loss of regulatory T cell (Treg)-mediated immunological tolerance to plaque antigens. Yet, the association between alterations of...

Full description

Bibliographic Details
Main Authors: Sebastian Dietmar Barth, Rudolf Kaaks, Theron Johnson, Verena Katzke, Katharina Gellhaus, Janika Josephin Schulze, Sven Olek, Tilman Kühn
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:EBioMedicine
Subjects:
Foxp3+ regulatory T cells (Tregs)
Cell-type-specific epigenetic qPCR-assays
Immune tolerance
Prospective study
Cardiovascular disease risk
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416303474

Internet

http://www.sciencedirect.com/science/article/pii/S2352396416303474

Similar Items