Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity.

Beta-amyloid (Aβ ) neurotoxicity is important in Alzheimer's disease (AD) pathogenesis. Aβ neurotoxicity causes oxidative stress, inflammation and mitochondrial damage resulting in neuronal degeneration and death. Oxidative stress, inflammation and mitochondrial failure are also pathophysiologi...

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Main Authors: Koon-Ho Chan, Karen Siu-Ling Lam, On-Yin Cheng, Jason Shing-Cheong Kwan, Philip Wing-Lok Ho, Kenneth King-Yip Cheng, Sookja Kim Chung, Jessica Wing-Man Ho, Vivian Yawei Guo, Almin Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3531475?pdf=render