4‐phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR‐α

4‐phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR‐α

Abstract Background and aims 4‐phenylbutyric acid (4‐PBA) is a low molecular weight fatty acid that is used in clinical practice to treat inherited urea cycle disorders. In previous reports, it acted as a chemical chaperone inhibiting endoplasmic reticulum (ER) stress and unfolded protein response s...

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Bibliographic Details
Main Authors: Shu‐Zhen Chen, Yan Ling, Le‐Xing Yu, Yu‐Ting Song, Xiao‐Fei Chen, Qi‐Qi Cao, Han Yu, Can Chen, Jiao‐Jiao Tang, Zhe‐Cai Fan, Yu‐Shan Miao, Ya‐Ping Dong, Jun‐Yan Tao, Satdarshan P.S. Monga, Wen Wen, Hong‐Yang Wang
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Clinical and Translational Medicine
Subjects:
4‐phenylbutyric acid (4‐PBA)
cancer stem cell (CSC)
hepatocellular carcinoma (HCC)
peroxisome proliferator‐activated receptor‐α (PPAR‐α)
Online Access:https://doi.org/10.1002/ctm2.379

Internet

https://doi.org/10.1002/ctm2.379

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