Different Expression Levels of Human Mutant Ubiquitin B+1 (UBB+1) Can Modify Chronological Lifespan or Stress Resistance of Saccharomyces cerevisiae

Different Expression Levels of Human Mutant Ubiquitin B+1 (UBB+1) Can Modify Chronological Lifespan or Stress Resistance of Saccharomyces cerevisiae

The ubiquitin-proteasome system (UPS) is the main pathway responsible for the degradation of misfolded proteins, and its dysregulation has been implicated in several neurodegenerative diseases, including Alzheimer’s disease (AD). UBB+1, a mutant variant of ubiquitin B, was found to accumulate in neu...

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Bibliographic Details
Main Authors: Ana Joyce Muñoz-Arellano, Xin Chen, Andrea Molt, Eugenio Meza, Dina Petranovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
UBB+1
proteasome
Alzheimer’s disease
aging
cell death
yeast
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00200/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00200/full

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