Loss of Wwox Perturbs Neuronal Migration and Impairs Early Cortical Development

Loss of Wwox Perturbs Neuronal Migration and Impairs Early Cortical Development

Mutations in the WWOX gene cause a broad range of ultra-rare neurodevelopmental and brain degenerative disorders, associated with a high likelihood of premature death in animal models as well as in humans. The encoded Wwox protein is a WW domain-containing oxidoreductase that participates in crucial...

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Bibliographic Details
Main Authors: Michele Iacomino, Simona Baldassari, Yuki Tochigi, Katarzyna Kośla, Francesca Buffelli, Annalaura Torella, Mariasavina Severino, Dario Paladini, Luana Mandarà, Antonella Riva, Marcello Scala, Ganna Balagura, Andrea Accogli, Vincenzo Nigro, Carlo Minetti, Ezio Fulcheri, Federico Zara, Andrzej K. Bednarek, Pasquale Striano, Hiroetsu Suzuki, Vincenzo Salpietro
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neuroscience
Subjects:
WWOX
WOREE syndrome
neuropathology
animal model
developing brain
cytoskeleton
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00644/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00644/full

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