CAR-T with License to Kill Solid Tumors in Search of a Winning Strategy

Artificial receptors designed for adoptive immune therapies need to absolve dual functions: antigen recognition and abilities to trigger the lytic machinery of reprogrammed effector T lymphocytes. In this way, CAR-T cells deliver their cytotoxic hit to cancer cells expressing targeted tumor antigens...

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Bibliographic Details
Main Authors: Benedetto Sacchetti, Andrea Botticelli, Luca Pierelli, Marianna Nuti, Maurizio Alimandi
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/20/8/1903