Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: Role in excitotoxicity

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: Role in excitotoxicity

Calcineurin is a serine/threonine phosphatase involved in the regulation of glutamate receptors signaling. Here, we analyzed whether the regulation of calcineurin protein levels and activity modulates the susceptibility of striatal neurons to excitotoxicity in R6/1 and R6/1:BDNF+/− mouse models of H...

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Bibliographic Details
Main Authors: Xavier Xifró, Albert Giralt, Ana Saavedra, Juan M. García-Martínez, Miguel Díaz-Hernández, José J. Lucas, Jordi Alberch, Esther Pérez-Navarro
Format: Article
Language:English
Published: Elsevier 2009-12-01
Series:Neurobiology of Disease
Subjects:
Calcineurin A
Calcineurin B
Conditional mouse model
Huntingtin
Quinolinic acid
R6/1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002393

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http://www.sciencedirect.com/science/article/pii/S0969996109002393

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