Identification of Serine 119 as an Effective Inhibitor Binding Site of M. tuberculosis Ubiquitin-like Protein Ligase PafA Using Purified Proteins and M. smegmatis

Identification of Serine 119 as an Effective Inhibitor Binding Site of M. tuberculosis Ubiquitin-like Protein Ligase PafA Using Purified Proteins and M. smegmatis

Owing to the spread of multidrug resistance (MDR) and extensive drug resistance (XDR), there is a pressing need to identify potential targets for the development of more-effective anti-M. tuberculosis (Mtb) drugs. PafA, as the sole Prokaryotic Ubiquitin-like Protein ligase in the Pup-proteasome Syst...

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Bibliographic Details
Main Authors: He-Wei Jiang, Daniel M. Czajkowsky, Tao Wang, Xu-De Wang, Jia-bin Wang, Hai-Nan Zhang, Cheng-Xi Liu, Fan-Lin Wu, Xiang He, Zhao-Wei Xu, Hong Chen, Shu-Juan Guo, Yang Li, Li-Jun Bi, Jiao-Yu Deng, Jin Xie, Jian-Feng Pei, Xian-En Zhang, Sheng-Ce Tao
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396418301129

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http://www.sciencedirect.com/science/article/pii/S2352396418301129

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