Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice
Broadly reactive antibodies that recognize influenza A virus HA can be protective, but the mechanism is not completely understood. Here, He et al. show that the inflammatory response and phagocytosis mediated by the interaction between protective antibodies and macrophages are essential for protecti...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00928-3 |
| id |
doaj-ecc73d871ca24888b8f3af7ce766d50b |
|---|---|
| record_format |
Article |
| spelling |
doaj-ecc73d871ca24888b8f3af7ce766d50b2021-05-11T07:29:02ZengNature Publishing GroupNature Communications2041-17232017-10-018111410.1038/s41467-017-00928-3Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in miceWenqian He0Chi-Jene Chen1Caitlin E. Mullarkey2Jennifer R. Hamilton3Christine K. Wong4Paul E. Leon5Melissa B. Uccellini6Veronika Chromikova7Carole Henry8Kevin W. Hoffman9Jean K. Lim10Patrick C. Wilson11Matthew S. Miller12Florian Krammer13Peter Palese14Gene S. Tan15Department of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The Committee on Immunology, The University of ChicagoDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The Committee on Immunology, The University of ChicagoDepartment of Biochemistry and Biomedical Sciences, Institute of Infectious Diseases Research, McMaster Immunology Research Centre, McMaster UniversityDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiBroadly reactive antibodies that recognize influenza A virus HA can be protective, but the mechanism is not completely understood. Here, He et al. show that the inflammatory response and phagocytosis mediated by the interaction between protective antibodies and macrophages are essential for protection.https://doi.org/10.1038/s41467-017-00928-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Wenqian He Chi-Jene Chen Caitlin E. Mullarkey Jennifer R. Hamilton Christine K. Wong Paul E. Leon Melissa B. Uccellini Veronika Chromikova Carole Henry Kevin W. Hoffman Jean K. Lim Patrick C. Wilson Matthew S. Miller Florian Krammer Peter Palese Gene S. Tan |
| spellingShingle |
Wenqian He Chi-Jene Chen Caitlin E. Mullarkey Jennifer R. Hamilton Christine K. Wong Paul E. Leon Melissa B. Uccellini Veronika Chromikova Carole Henry Kevin W. Hoffman Jean K. Lim Patrick C. Wilson Matthew S. Miller Florian Krammer Peter Palese Gene S. Tan Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice Nature Communications |
| author_facet |
Wenqian He Chi-Jene Chen Caitlin E. Mullarkey Jennifer R. Hamilton Christine K. Wong Paul E. Leon Melissa B. Uccellini Veronika Chromikova Carole Henry Kevin W. Hoffman Jean K. Lim Patrick C. Wilson Matthew S. Miller Florian Krammer Peter Palese Gene S. Tan |
| author_sort |
Wenqian He |
| title |
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice |
| title_short |
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice |
| title_full |
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice |
| title_fullStr |
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice |
| title_full_unstemmed |
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice |
| title_sort |
alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza a virus in mice |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-10-01 |
| description |
Broadly reactive antibodies that recognize influenza A virus HA can be protective, but the mechanism is not completely understood. Here, He et al. show that the inflammatory response and phagocytosis mediated by the interaction between protective antibodies and macrophages are essential for protection. |
| url |
https://doi.org/10.1038/s41467-017-00928-3 |
| work_keys_str_mv |
AT wenqianhe alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT chijenechen alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT caitlinemullarkey alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT jenniferrhamilton alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT christinekwong alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT pauleleon alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT melissabuccellini alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT veronikachromikova alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT carolehenry alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT kevinwhoffman alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT jeanklim alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT patrickcwilson alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT matthewsmiller alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT floriankrammer alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT peterpalese alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice AT genestan alveolarmacrophagesarecriticalforbroadlyreactiveantibodymediatedprotectionagainstinfluenzaavirusinmice |
| _version_ |
1721452190794514432 |