PD/1-PD-Ls Checkpoint: Insight on the Potential Role of NK Cells

PD/1-PD-Ls Checkpoint: Insight on the Potential Role of NK Cells

The identification of inhibitory NK cell receptors specific for HLA-I molecules (KIRs and NKG2A) provided the molecular basis for clarifying the mechanism by which NK cells kill transformed cells while sparing normal cells. The direct interactions between inhibitory NK cell receptors and their HLA-I...

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Bibliographic Details
Main Authors: Silvia Pesce, Marco Greppi, Francesco Grossi, Genny Del Zotto, Lorenzo Moretta, Simona Sivori, Carlo Genova, Emanuela Marcenaro
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
NK cells
PD-1
PD-L
KIR
NKG2A
immune checkpoint
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01242/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01242/full

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