Esculetin ameliorates insulin resistance and type 2 diabetic nephropathy through reversal of histone H3 acetylation and H2A lysine 119 monoubiquitination

Esculetin ameliorates insulin resistance and type 2 diabetic nephropathy through reversal of histone H3 acetylation and H2A lysine 119 monoubiquitination

Insulin resistance (IR) and type 2 diabetic nephropathy (T2DN) are associated with elevated renal expression of monocyte chemo-attractant protein (MCP1) and transforming growth factor-β (TGF-β). Posttranslational histone modifications (PTHMs) play significant role in regulating the expression of suc...

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Bibliographic Details
Main Authors: Almesh Kadakol, Vajir Malek, Santosh Kumar Goru, Anuradha Pandey, Nisha Sharma, Anil Bhanudas Gaikwad
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Journal of Functional Foods
Subjects:
Epigenetics
Esculetin
Insulin resistance
Fibrosis
Type 2 diabetes
Diabetic nephropathy
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464617303055

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http://www.sciencedirect.com/science/article/pii/S1756464617303055

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