Def6 regulates endogenous type-I interferon responses in osteoblasts and suppresses osteogenesis

Bone remodeling involves a balance between bone resorption and formation. The mechanisms underlying bone remodeling are not well understood. DEF6 is recently identified as a novel loci associated with bone mineral density. However, it is unclear how Def6 impacts bone remodeling. We identify Def6 as...

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Bibliographic Details
Main Authors: Zhonghao Deng, Courtney Ng, Kazuki Inoue, Ziyu Chen, Yuhan Xia, Xiaoyu Hu, Matthew Greenblatt, Alessandra Pernis, Baohong Zhao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/59659