Functional characterization of the defective CYP2C9 variant CYP2C9*18

Functional characterization of the defective CYP2C9 variant CYP2C9*18

Abstract Cytochrome P450 2C9 (CYP2C9) is one of the most important drugs metabolizing enzymes and accounts for the metabolism of about 13%–17% of clinical drugs. Like other members in CYP2 family, CYP2C9 gene exhibits great genetic polymorphism among different races and individuals. CYP2C9*18 is one...

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Bibliographic Details
Main Authors: Jian Liu, Hao Chen, Shuang‐Hu Wang, Quan Zhou, Pei‐Wu Geng, Yun‐Fang Zhou, Hua‐Lan Wu, Hai‐Feng Shi, Fang Wang, Jie‐Fu Yang, Jian‐Ping Cai, Da‐Peng Dai
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Pharmacology Research & Perspectives
Subjects:
allelic variant
baculovirus
CYP2C9
metabolic characterization
probe substrate
Online Access:https://doi.org/10.1002/prp2.718

Internet

https://doi.org/10.1002/prp2.718

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