Serine Phosphorylation of L-Selectin Regulates ERM Binding, Clustering, and Monocyte Protrusion in Transendothelial Migration

Serine Phosphorylation of L-Selectin Regulates ERM Binding, Clustering, and Monocyte Protrusion in Transendothelial Migration

The migration of circulating leukocytes toward damaged tissue is absolutely fundamental to the inflammatory response, and transendothelial migration (TEM) describes the first cellular barrier that is breached in this process. Human CD14+ inflammatory monocytes express L-selectin, bestowing a non-can...

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Bibliographic Details
Main Authors: Abigail Newe, Karolina Rzeniewicz, Melanie König, Carsten F. E. Schroer, Justin Joachim, Angela Rey-Gallardo, Siewert J. Marrink, Jürgen Deka, Maddy Parsons, Aleksandar Ivetic
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
förster resonance energy transfer (FRET)
fluorescence lifetime imaging microscopy (FLIM)
molecular dynamics
extravasation
diapedesis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02227/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02227/full

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