Identification of putative causal loci in whole-genome sequencing data via knockoff statistics

Identification of putative causal loci in whole-genome sequencing data via knockoff statistics

Association analyses that capture rare and noncoding variants in whole genome sequencing data are limited by factors like statistical power. Here, the authors present KnockoffScreen, a statistical method using the knockoff framework to detect, localise and prioritise rare and common risk variants at...

Full description

Bibliographic Details
Main Authors: Zihuai He, Linxi Liu, Chen Wang, Yann Le Guen, Justin Lee, Stephanie Gogarten, Fred Lu, Stephen Montgomery, Hua Tang, Edwin K. Silverman, Michael H. Cho, Michael Greicius, Iuliana Ionita-Laza
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22889-4

Internet

https://doi.org/10.1038/s41467-021-22889-4

Similar Items