GS-CA Compounds: First-In-Class HIV-1 Capsid Inhibitors Covering Multiple Grounds

GS-CA Compounds: First-In-Class HIV-1 Capsid Inhibitors Covering Multiple Grounds

Recently reported HIV-1 capsid (CA) inhibitors GS-CA1 and GS-6207 (an analog of GS-CA1) are first-in-class compounds with long-acting potential. Reportedly, both compounds have greater potency than currently approved anti-HIV drugs. Due to the limited access to experimental data and the compounds th...

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Bibliographic Details
Main Authors: Kamal Singh, Fabio Gallazzi, Kyle J. Hill, Donald H. Burke, Margaret J. Lange, Thomas P. Quinn, Ujjwal Neogi, Anders Sönnerborg
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Microbiology
Subjects:
human immunodeficiency virus
capsid
assembly
small molecules
inhibitors
disassembly
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01227/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01227/full

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