Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation

Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation

In this work<b> </b>we summarize our understanding of melanocortin 4 receptor (MC4R) pathway activation, aiming to define a safe and effective therapeutic targeting strategy for the MC4R. Delineation of cellular MC4R pathways has provided evidence for distinct MC4R signaling events chara...

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Bibliographic Details
Main Authors: Shubh Sharma, Alastair S. Garfield, Bhavik Shah, Patrick Kleyn, Ilia Ichetovkin, Ida Hatoum Moeller, William R. Mowrey, Lex H.T. Van der Ploeg
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
melanocortin-4 receptor
obesity
peptide agonist
cardiovascular profile
GαS signaling
receptor desensitization
receptor internalization
Online Access:https://www.mdpi.com/1420-3049/24/10/1892

Internet

https://www.mdpi.com/1420-3049/24/10/1892

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