Transient, flexible gene editing in zebrafish neutrophils and macrophages for determination of cell-autonomous functions

Transient, flexible gene editing in zebrafish neutrophils and macrophages for determination of cell-autonomous functions

Zebrafish are an important model for studying phagocyte function, but rigorous experimental systems to distinguish whether phagocyte-dependent effects are neutrophil or macrophage specific have been lacking. We have developed and validated transgenic lines that enable superior demonstration of cell-...

Full description

Bibliographic Details
Main Authors: Abdulsalam I. Isiaku, Zuobing Zhang, Vahid Pazhakh, Harriet R. Manley, Ella R. Thompson, Lucy C. Fox, Satwica Yerneni, Piers Blombery, Graham J. Lieschke
Format: Article
Language:English
Published: The Company of Biologists 2021-07-01
Series:Disease Models & Mechanisms
Subjects:
cell autonomy
crispr-cas9
gene editing
macrophages
neutrophils
zebrafish
Online Access:http://dmm.biologists.org/content/14/7/dmm047431

Internet

http://dmm.biologists.org/content/14/7/dmm047431

Similar Items