Inhibition of EZH2 ameliorates cartilage endplate degeneration and attenuates the progression of intervertebral disc degeneration via demethylation of Sox-9

Inhibition of EZH2 ameliorates cartilage endplate degeneration and attenuates the progression of intervertebral disc degeneration via demethylation of Sox-9

Background: Cartilaginous endplate (CEP) degeneration is considered as one of the major causes of intervertebral disc degeneration (IVDD) which causes low back pain. Recent studies have proved that epigenetic alteration is involved in a variety of diseases. This work explored the role of histone met...

Full description

Bibliographic Details
Main Authors: Chao Jiang, Qiang Guo, Yu Jin, Jia-Jing Xu, Ze-Ming Sun, Ding-Chao Zhu, Jia-Hao Lin, Nai-Feng Tian, Liao-Jun Sun, Xiao-Lei Zhang, Yao-Sen Wu
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641930670X

Internet

http://www.sciencedirect.com/science/article/pii/S235239641930670X

Similar Items