In vivo Pharmacokinetic Drug-Drug Interaction Studies Between Fedratinib and Antifungal Agents Based on a Newly Developed and Validated UPLC/MS-MS Method

In vivo Pharmacokinetic Drug-Drug Interaction Studies Between Fedratinib and Antifungal Agents Based on a Newly Developed and Validated UPLC/MS-MS Method

In the current research experiment, a sensitive, precise and rapid bioanalytical approach involving the detection of fedratinib concentrations in rat plasma by ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) technique was optimized and established, and it was employed t...

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Bibliographic Details
Main Authors: Congrong Tang, Xiaohui Niu, Lu Shi, Huidan Zhu, Guanyang Lin, Ren-ai Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
fedratinib
CYP3A4
UPLC-MS/MS
drug-drug interaction
pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.626897/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.626897/full

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