Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against <it>Schistosoma mansoni</it>-induced liver fibrosis

Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against <it>Schistosoma mansoni</it>-induced liver fibrosis

<p>Abstract</p> <p>Background</p> <p>Praziquantel (PZQ) is an isoquinoline derivative (2-cyclohexylcarbonyl-1, 2, 3, 6, 7, 11b-hexahydro-4H-pyrazino{2,1-a}-isoquinoline-4-one), and is currently the drug of choice for all forms of schistosomiasis. Silymarin, a standardiz...

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Bibliographic Details
Main Authors: El-Lakkany Naglaa M, Hammam Olfat A, El-Maadawy Walaa H, Badawy Afkar A, Ain-Shoka Afaf A, Ebeid Fatma A
Format: Article
Language:English
Published: BMC 2012-01-01
Series:Parasites & Vectors
Subjects:
<it>Schistosoma mansoni</it>
silymarin
praziquantel
liver fibrosis
hydroxyproline
transforming growth factor-β1
matrix metalloproteinase-2
mast cells
Online Access:http://www.parasitesandvectors.com/content/5/1/9

Internet

http://www.parasitesandvectors.com/content/5/1/9

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