Epistatic Interactions between apolipoprotein E and hemoglobin S Genes in regulation of malaria parasitemia.

Epistatic Interactions between apolipoprotein E and hemoglobin S Genes in regulation of malaria parasitemia.

Apolipoprotein E is a monomeric protein secreted by the liver and responsible for the transport of plasma cholesterol and triglycerides. The APOE gene encodes 3 isoforms Ɛ4, Ɛ3 and Ɛ2 with APOE Ɛ4 associated with higher plasma cholesterol levels and increased pathogenesis in several infectious disea...

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Bibliographic Details
Main Authors: Virginie Rougeron, Caira M Woods, Kathryn E Tiedje, Florence Bodeau-Livinec, Florence Migot-Nabias, Philippe Deloron, Adrian J F Luty, Freya J I Fowkes, Karen P Day
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3792892?pdf=render

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http://europepmc.org/articles/PMC3792892?pdf=render

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