Lysophosphatidylcholine-induced mitochondrial fission contributes to collagen production in human cardiac fibroblasts[S]

Lysophosphatidylcholine-induced mitochondrial fission contributes to collagen production in human cardiac fibroblasts[S]

Lysophosphatidylcholine (LPC) may accumulate in the heart to cause fibrotic events, which is mediated through fibroblast activation and collagen accumulation. Here, we evaluated the mechanisms underlying LPC-mediated collagen induction via mitochondrial events in human cardiac fibroblasts (HCFs), co...

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Bibliographic Details
Main Authors: Hui-Ching Tseng, Chih-Chung Lin, Li-Der Hsiao, Chuen-Mao Yang
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Journal of Lipid Research
Subjects:
heart
cell signaling
extracellular matrix
inflammation
lysophospholipid
cardiac fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520323191

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http://www.sciencedirect.com/science/article/pii/S0022227520323191

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